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KMID : 0360220210620060769
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 6 p.769 ~ p.776
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Microvasculature and Nerve Fiber Layer-Ganglion Cell Inner Plexiform Layer Thickness in Type 2 Diabetes
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Seo Jin-Seok
Cho Yong-Wun
Seo Seong-Wook
Kim Seong-Jae
Chung In-Young
Yoo Woong-Sun
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Abstract
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Purpose: To investigate thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and vessel density of the superficial and deep retinal vessels and choriocapillaris using swept source optical coherence tomography (SS-OCT) and angiography (OCTA) in type 2 diabetic patients without diabetic retinopathy (DR).
Methods: Sixty-four eyes of type 2 diabetic patients without DR were included. A control group of 54 eyes without diabetes was also recruited. All patients underwent multimodal imaging evaluation using SS-OCT and OCTA.
Results: Vessel density of the superficial and deep retinal vessels was not different between the study and control groups. A significant decrease in NFL-GCIPL complex thickness was observed in the study group compared to the control group. NFL-GCIPL thickness of the macula decreased with increased duration of diabetes.
Conclusions: These results suggest that neurodegeneration might be an early change in the development of DR.
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KEYWORD
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Diabetic retinopathy, Neurodegeneration, Optical coherence tomography, Optical coherence tomographic angiography
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